DNA, RNA, Chromosomes, and Genes

History of Nucleic Acids

What is the “RNA Tie Club”?

In 1953, shortly after the publication of James Watson (1920–1958) and Francis Crick’s (1916-2004) paper on the structure of DNA, George Gamow (1904–1968), a Russian physicist, wrote to Watson and Crick and suggested a mathematical link between DNA structure and the structure of twenty amino acids. The “RNA Tie Club” was an outgrowth of this proposal; members included Watson, Crick, and seventeen others, each taking a nickname from one of the twenty amino acids. Each member of the club was presented with a specially designed tie corresponding to the appropriate amino acid.


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