No, he and President Adams parted company on many political issues of the day. Jefferson did not take an active part in the administration. He actively opposed the administration on many matters. For example, he campaigned and wrote against the Sedition Act of 1798 that President Adams had signed into law.

Jefferson did preside over the Senate—the main constitutional duty of vice presidents. He wrote The Manual of Parliamentary Practice, which became the leading rulebook for members of both houses of Congress.