Endocrine System


How do paracrine hormones differ from circulating hormones?

Local hormones become active without first entering the bloodstream. They act locally on the same cell that secreted them or on neighboring cells. Local secretion of proinflammatory factors increases extravasation from blood vessels to produce local edema and flare responses. Circulating hormones are more prevalent than local hormones. Once secreted, they enter the bloodstream to be transported to their target cells.


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